Comparison of Noninvasive Tests in Indian NAFLD Patients

Background and Aim: Simple non-invasive tests for liver fibrosis like APRI, BARD, NFS, FIB-4 are easy to perform, cheap. Studies showed that fibroscan has good sensitivity in detecting NAFLD, but it is not available widely [1, 2]. There paucity of data about these noninvasive prediction Indian NAFLD patients. Aim this study compare various scores (APRI, FIB-4) with fibro-scan biopsy predict Methods: Patients attending Gastroenterology OPD dyspepsia, IBS other Gastrointestinal complaints were screened the by abdominal USG. Age sex matched healthy controls recruited from attendants Noninvasive score (NFS), Aspartate-aminotransferase (AST)/platelet ratio (APRI), Fib-4, BARD calculated. Measurement hepatic stiffness was done Transient Elastography (TE) liver-biopsy performed patients who gave consent procedure. Results: Total number 909 mean age BMI 41.5 ± 9.5 years 26.64± 3.37 kg/m sq respectively. The AUROC under FIBROSCAN 0.474, 0.579, 0.595, 0.633, 0.987 At a cut-off 1.36, 1.24, 2, 1.55 7.95 20%, 84%, 50%, 65% 80% sensitive 83%, 80%, 78%, 87%, 92% specific Conclusion: Fibroscan had best among 0.987. Blood based less advanced Indians than western population. 7.45 80, 92%, 76.92%, 93.04% sensitivity, specificity, PPV NPV FIB-4, NFS can be utilized as screening tools rull-out NPV.